目的：探讨急性脑梗死患者血浆同型半胱氨酸（Hcy）与超敏C反应蛋白（hs-CRP）、血管性假血友病因子（vWF）水平的相关性及临床意义。方法选取急性脑梗死患者150例，按照其血浆 H cy增高程度不同分为3组。另外，选取同期健康体检者50例作为对照组，分别测定急性脑梗死患者和对照组健康者血浆hs-CRP、vWF及 Hcy水平并进行组间比较，并对hs-CRP与Hcy、vWF与Hcy的检测结果进行相关性分析。结果急性脑梗死患者血浆hs-CRP、vWF及 Hcy水平显著高于对照组（P＜0．05）；急性脑梗死患者血浆hs-CRP、vWF升高水平与Hcy升高水平呈正相关。急性脑梗死患者各组 Hcy、hs-CRP、vWF水平均显著高于对照组（P＜0．05）。结论血浆hs-CRP、vWF、Hcy可作为血管内皮损伤的标志物，这三项指标的联合检测可以为急性脑梗死早期诊断和治疗提供依据。%Objective To investigate the correlation between plasma homocysteine (Hcy) and high sensitivity C-reactive protein (hs-CRP) ,Hcy and von Willebrand factor(vWF) in patients with acute cerebral infarction ,and to analyze their clinical significance . Methods 150 patients with acute cerebral infarction were enrolled in the study ,and were divided into 3 groups according to their plasma Hcy concentrations .Meanwhile 50 healthy people were recruited as control group .Plasma hs-CRP ,vWF and Hcy concentra-tions were determined and compared between groups .Then data correlation analysis was performed .Results In patients with acute cerebral infarction plasma hs-CRP ,vWF and Hcy concentrations were significantly higher than those in healthy control group (P<0 .05) .Plasma Hcy concentrations in patients with acute cerebral infarction were positively correlated with plasma hs-CRP and vWF concentrations .Conclusion Hs-CRP ,vWF and Hcy are biomarkers of endothelial injury ,the combined detection of the three indica-tors might contribute to the early diagnosis and treatment of acute cerebral infarction .
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