儿童微量元素以及血铅水平与贫血的相关性分析

摘要

Objective To analyze the relationship between anemia and blood levels of lead and trace elements in children,and to provide basis for the prevention and treatment of anemia.Methods 80 children with anemia(case group)and 90 health children (control group)were enrolled in the study.The blood levels of trace elements (iron,zinc,calcium,magnesium,copper)and lead were detected in all subjects,in order to analyze their correlations with anemia.Results Compared with control group,the blood levels of iron,zinc and magnesium in case group were significantly lower(P<0.05),while the blood levels of calcium and lead were significantly higher(P<0.05).The blood level of copper in case group was close to that in control group(P>0.05).With the re-duction of iron,zinc and magnesium and the rise of calcium and lead,the severity of anemia increased significantly(P<0.05). Effects of copper level on the severity of anemia was not obvious(P>0.05).The blood level of iron was positive correlated with Hb,RBC and MCH (P<0.05).The blood level of zinc was positive correlated with Hb and MCH(P<0.05).The blood level of lead was negative correlated with Hb,MCV and MCH(P<0.05).Conclusion The blood level changes of trace elements and leas effect the severity of anemia in children.It is necessary to test the blood levels of trace elements and lead.%目的：探讨微量元素以及血铅水平与儿童发生贫血的相关性，为临床防治贫血提供可参考依据。方法连续收集85例诊断为贫血的患儿作为病例组，同时从门诊随机抽取90例健康体检儿童作为对照组，对受试者进行微量元素（铁、锌、钙、镁、铜）及血铅水平的检测，分析检测结果与贫血程度的相关性。结果与对照组相比，病例组患儿血中铁、锌、镁浓度明显比较低，而钙、铅浓度明显高于对照组，2组间比较差异有统计学意义（P＜0．05）。2组血中铜浓度差异无统计学意义（P＞0．05）。随着患儿血中铁浓、锌、镁浓度的降低，钙、铅浓度的上升，贫血严重程度明显增加（P＜0．05）；而血中铜浓度变化对贫血程度影响不明显（P＞0．05）。血铁浓度与 Hb、RBC及 MCH 呈正相关（P＜0．05）；血锌浓度与 Hb及 MCH 呈正相关（P＜0．05）；血铅浓度与Hb、MCV及 MCH 呈负相关（P＜0．05）。结论多种微量元素浓度的变化及血铅水平的升高影响儿童贫血的严重程度，因此有必要对相关微量元素及血铅进行检测。