老年冠心病患者胱抑素 C、巨噬细胞移动抑制因子及基质金属蛋白酶-1在血清中的表达分析

摘要

目的：探讨老年冠心病患者血清胱抑素 C、巨噬细胞移动抑制因子(MIF)、基质金属蛋白酶-1(MMP-1)在不同病变程度中的表达差异。方法选取心血管内科2012年7月至2014年8月收治的老年冠心病患者120例,根据冠状动脉造影结果并结合心电图、心肌酶谱等检查将其分为对照组(30例)、稳定型心绞痛组(SAP 组,34例)、不稳定型心绞痛组(UA 组,28例)、急性心肌梗死组(AMI 组,28例)。比较4组患者血清胱抑素 C、MIF、MMP-1及高敏 C 反应蛋白(hs-CRP)水平,并进行4项指标间的相关性分析。结果4组患者血清胱抑素 C、MIF、MMP-1及 hs-CRP 水平比较差异均有统计学意义(P <0.05)；血清胱抑素C、MIF、MMP-1水平均随病情进展逐渐增加,且组间两两比较差异均有统计学意义(P <0.05)；AMI 组患者血清 hs-CRP 水平与其余3组比较差异均有统计学意义(P <0.05)；对照组、SPA 组和 UA 组患者血清 hs-CRP 水平两两比较差异均无统计学意义(P >0.05)。胱抑素 C、MIF、MMP-1三者间呈明显正相关。结论冠心病患者血清胱抑素 C、MIF 和 MMP-1水平,随着病情的加重有逐渐升高的趋势,可作为病情评估的重要指标。%Objective To explore the differences of serum expression of cystatin C,macrophage migration inhibitory factor (MIF)and matrix metalloproteinase-1 (MMP-1)in elderly patients with coronary artery disease.Methods 120 cases of senile cor-onary heart disease patients in the department of cardiovascular medicine from July 2010 to August 2012 were selected and divided into the control group (n=30),stable angina pectoris group(SAP group,n= 34),unstable angina group (UA group,n=28)and a-cute myocardial infarction group (AMI group,n=28)according to the results of coronary arteriography combined with the electro-cardiogram and myocardial enzyme spectrum test.The serum levels of cystatin C,MIF,MMP-1 and C reactive protein (hs-CRP) were compared among the four groups,and correlations of the four indicators were analysed as well.Results There were significant differences in the serum levels of cystatin C,MIF,MMP-1 and hs-CRP among the four groups(P <0.05).The serum levels of cys-tatin C,MIF and MMP-1 were gradually increased with the progression of disease,and significant differences were found between any two groups(P <0.05).There were significant differences in the levels of hs-CRP between the AIM group and the other three groups(P <0.05).While among the control group,SPA group and UA group,no significant differences were found in the levels of hs-CRP between any two groups(P >0.05).The significant positive correlations were observed among cystatin C,MIF and MMP-1.Conclusion The serum levels of cystatin C,MIF and MMP-1 have a gradually increasing trend with disease progression in pa-tients with coronary heart disease,which could be important indicators of disease evaluation.