Matrix Metalloproteases, Chitotriosidase, and Cystatin C in a long-term study in patients after cardiosurgery

摘要

Potent non-lipid markers of atherosclerosis - matrix metalloproteases (MMP), chitotriosidase and cystatin C - were assayed in long-term (1, 2 and 3 years) study of patients after coronary bypass surgery. Patients with prior ischemic heart disease (IHD) had demonstrated significantly elevated levels of CRP-hs, total cholesterol and TG, cystatin C, MMP and chitotriosidase activity. Following surgery there was a tendency for a decrease in CRP-hs and serum lipids (at 1 and 2 years after the operation, especially in the statin-treated group), however, all indexes studied were still elevated vs the control group of low IHD risk. The hypolipidemic effect of simvastatin in IHD patients was shown to correlate with decreased CRP-hs level and MMP activity, associated with the pleiotropic effect of statins.