血清视黄醇结合蛋白检测对2型糖尿病患者早期肾功能损伤诊断的价值

摘要

Objective To evaluate the diagnostic value of serum retinol binding protein (RBP) on the early stage of type 2 diabet‐ic nephropathy by receiver operating characteristic(ROC)curve .Methods According to urinary albumin(mAlb)/urinary creatinine (UCr) ratio ,155 patients with type 2 diabetes were divided into simple diabetic mellitus group ,early stage of diabetic nephropathy group ,and clinical stage of diabetic nephropathy group ,while healthy people were recruited randomly during the same period as con‐trol group .RBP test were performed by using immunoturbidimetry .The diagnostic value of RBP on in the early stage of type 2 dia‐betic nephropathy were evaluated by analyzing the ROC curve .Results The concentration of serum RBP in the early stage of dia‐betic nephropathy was significantly higher than that in the group of simple diabetic mellitus and control group (P<0 .05) ,the area under the ROC curve of RBP in serum was 0 .770 ,and the cutoff value was 40 .95 mmol/L ,while the sensitivity and the specificity were 81 .0% and 95 .2% .Conclusion RBP was a good marker in detecting early renal damage .%目的：应用受试者工作特征（ROC）曲线评价血清视黄醇结合蛋白（RBP）检测在2型糖尿病（T2DM ）早期肾功能损伤中的应用价值。方法将155例临床确诊为T2DM的患者按照尿微量清蛋白（mAlb）／尿肌酐（UCr）比值分为单纯糖尿病组、早期糖尿病肾病组和临床糖尿病肾病组；另外选取同一时期进行健康体检且合格者作为对照组；比较各组间的差异，同时通过ROC曲线评价RBP在糖尿病早期肾功能损伤中的诊断价值。结果早期糖尿病肾病组与对照组、单纯糖尿病组比较，RBP水平差异均有统计学意义（P＜0．05）；血清RBP的ROC曲线下面积为0．770，灵敏度和特异度分别为81．0％、95．2％。结论 RBP检测有助于发现糖尿病患者早期肾功能损伤。