Objective To investigate clinical value of procalcitonin (PCT ) in guiding treatment of infection in elderly patients with heart failure .Methods A total of 120 cases of elderly patients with heart failure and infection were divided into control group (50 cases) ,receiving conventional anti-infection treatment ,and observation group(70 cases) ,receiving adjusted anti-infection treat-ment based on serum PCT levels .Treatment efficiency ,cost of treatment ,hospitalization duration and other indicators were com -pared between the two groups .Results Effective rate of observation group was 78 .57% ,which was not significantly different with the 78 .00% of control group ( P > 0 .05) .Cost of treatment ,hospitalization duration ,application time of antibiotics ,antibacterial drug costs ,superinfection and mortality were significantly different between the two groups (P< 0 .05) .After treatment ,levels of e-rythrocyte sedimentation rate ,C-reaction protein ,white blood cells and neutrophil in the two groups were significantly improved (P< 0 .05) .After treatment ,C-reaction protein level of observation group was lower than control group (P < 0 .05) .Conclusion PCT based anti-infection treatment could help shorten the treatment time ,reducing treatment costs and improving outcomes ,and might be worthy of clinical application .%目的：探讨降钙素原（PCT）监测指导老年心力衰竭患者抗感染治疗的临床应用效果。方法随机选择120例老年心力衰竭合并肺部感染患者，按自愿原则分为对照组（50例）与观察组（70例）。对照组根据症状及病情给予常规治疗。观察组根据血清 PCT 水平调整抗感染治疗方案。比较两组患者治疗有效率、治疗费用、住院时间等指标。结果观察组、对照组治疗有效率分别为78．57％、78．00％，比较差异无统计学意义（P＞0．05）。观察组、治疗组治疗费用、住院时间、抗菌药物使用时间、抗菌药物费用比较差异有统计学意义（P＜0．05）。观察组二重感染率、病死率低于对照组（P＜0．05）。与治疗前相比，观察组与对照组治疗后血细胞沉降率、C 反应蛋白（CRP）、白细胞计数、中性粒细胞比例均明显改善（P＜0．05），观察组治疗后 CRP 水平低于对照组（P＜0．05）。结论根据 PCT 水平指导老年心力衰竭患者抗感染治疗有利于缩短治疗时间、降低治疗成本、改善患者预后，值得临床推广应用。
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