下呼吸道感染患者痰标本中产ESBLs菌株的分布及耐药情况

摘要

Objective To study the distribution of bacterium extended spectrum beta lactamases (ESBLs) in sputum samples from patients with lower respiratory tract infection in Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine . Methods A total of 512 strains of gram negative bacterium were isolated from sputum samples of patients with lower respiratory tract infection from January 2014to January 2016 ,standard disk diffusion method was used to detected ESBLs ,drug sensitivity was performed by K-B disk diffusion method .Distribution and drug resistant status of ESBLs bacterium were analyzed .Results Detec-tion rate of ESBLs bacteriumin cadre ward and ICU were higher than that in department of respiration ,and the difference was sta-tistical significant(P< 0 .01) .Among ESBLs bacterium isolated from department of respiration ,Escherichia coli accounted for 37 .5% ,Enterobacter cloacae accounted for 25 .8% .Among ESBLs bacterium isolated from cadre ward ,Escherichia coli accounted for 58 .2% ,Enterobacter cloacae accounted for 45 .5% .The resistant rate of gram negative bacterium producing ESBLs to trime-thoprim was lowest .Conclusion It′s important to understand the distribution and drug resistant status of gram negative bacterium , so as to provide the basis for rational use of antibiotics .%目的 研究该院下呼吸道感染患者痰标本中产超广谱β-内酰胺酶(ESBLs)菌株的分布及耐药情况,为合理使用抗菌药物提供依据.方法 收集2014年1月至2016年1月该院下呼吸道感染患者的痰标本中分离出的革兰阴性杆菌512株,采用标准纸片扩散法对ESBLs进行检测,采用K-B纸片扩散法检测药敏,分析革兰阴性杆菌中产ESBLs菌的分布及耐药情况.结果 干部病房和ICU中,产ESBLs菌分离率高于呼吸科病房,且差异有统计学意义(P<0.01).呼吸科、干部病房及ICU分离的产ESBLs菌均以大肠埃希菌和阴沟肠杆菌为主.分离的产ESBLs革兰阴性菌对甲氧苄啶的耐药率最低.结论 掌握下呼吸道感染患者的病原菌分布及耐药情况,有利于辅助临床医师合理用药.