G-脂多糖检测在创伤性脑损伤患者中的临床应用研究

摘要

Objective To study the application value of G-lipopolysaccharides(G-LPS) detection in patients with traumatic brain injury(TBI).Methods From Jan.2013 to Jun.2014,plasma G-LPS of TBI-patients and non-patients in this hospital were detected by using MB-80 microbiology analyzer and compared.Results of pathogenic microbiological detection of G-LPS positive TBI patients were analyzed,and G-LPS levels,detected before and after treatment,were also analyzed.Results G-LPS positive rate of TBI patients(33.33%) was higher than the 13.34% of non-TBI patients(P<0.05).After treatment,G-LPS level in G-LPS positive TBI patients significantly decreased(P<0.05).The common pathogenic bacteria,causing infection in TBI patients,included Acinetobacter bauman,Klebsiella pneumoniae and Escherichia coli,and the most common infection diseases included respiratory tract infections and urinary tract infections.Conclusion G-LPS detection could be used for the early detection of secondary infection in TIB patients,with significance for guiding clinical treatment.%目的 探讨血浆G-脂多糖检测在创伤性脑损伤(TBI)患者中的临床应用价值.方法 于2013年1月至2014年6月,采用MB-80微生物快速动态检测系统对本院诊治的TBI患者和非TBI患者进行血浆G-脂多糖检测,并比较检测结果.分析G-脂多糖阳性TBI患者病原微生物检测结果,及治疗前后血浆G-脂多糖水平的变化.结果 TBI患者G-脂多糖检测阳性率(33.33%)高于非TBI患者检测阳性率(13.34%,P<0.05).与治疗前检测结果相比,G-脂多糖阳性TBI患者抗感染治疗后血浆G-脂多糖水平明显下降(P<0.05).G-脂多糖阳性TBI患者继发感染病原菌包括鲍曼不动杆菌、肺炎克雷伯菌、大肠埃希菌等,常见感染类型包括呼吸系统感染和泌尿系统感染.结论 G-脂多糖检测可用于TBI患者继发感染的早期诊断,对临床治疗具有一定的指导意义.