新疆地区老年2型糖尿病患者甲状腺结节的危险因素分析

摘要

目的 探讨新疆地区老年2型糖尿病(年龄≥60岁)患者甲状腺结节的患病情况及其相关危险因素.方法 选取老年2型糖尿病患者202例,其中,甲状腺结节患者91例(甲状腺结节组),非甲状腺结节组111例(对照),收集患者病史、体质量指数(BMI)、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等资料进行统计学分析.结果 年龄、性别、BMI、TC、HbA1c、BMI在两组间比较,差异有统计学意义(P<0.05);病程、脉压、收缩压、腹围、吸烟史、HDL、TG、FBG、2 h PBG在甲状腺结节组与非甲状腺结节组之间比较,差异均无统计学意义(P>0.05).多因素Logistic回归进行分析显示:性别、年龄、TC、HbA1c、BMI是甲状腺结节发生的危险因素.结论 对老年女性、肥胖、胆固醇升高的糖尿病患者进行甲状腺结节相关影像学检查具有重要临床意义.%Objective To explore the prevalence and related risk factors of thyroid nodule in elderly patients(age ≥ 60 years old) with type 2 diabetes mellitus(T2DM)) in Xinjiang region.Methods Two hundreds and two elderly patients with T2DM were selected,including 91 cases of thyroid nodule(thyroid nodule group) and111 cases of non-thyroid nodule (control group).The disease history,body mass index(BMI),fasting blood-glucose (FBG),2-h postprandial blood glucose(2 h PBG),glycosylated hemoglobin(HbA1c),triglyceride(TG),cholesterol(TC),high-density lipoprotein(HDL-C) and low density lipoprotein(LDL-C) were collected for statistical analysis.Results The age,gender,BMI,TC and HbA1c had statistical difference between the two groups (P<0.05);the disease course,pulse pressure,systolic pressure,abdominal perimeter,smoking history,HDL,TG,FBG and 2 h PBG had no statistical differences netween the thyroid nodule group and non-thyroid nodule group (P>0.05).The multivariable Logistic regression analysis showed that the age,gender,TC,HbA1c and BMI were the risk factors of thyroid nodule occurrence.Conclusion Conducting the thyroid nodule related imaging examination has an important clinical significance for diabetic elderly women patients with obesity and cholesterol increase.