Objective To investigate the distribution and antibiotics resistance of the major non-fermenting bacteria in our hospital from 2011 to 2016 ,then provide a reference for clinic practice .Methods Retrospective-ly analyze clinical distribution and antimicrobial susceptibility of 2398 non-fermenting bacteria from 2014 to 2016 .Results Over the past 3 years ,2398 main non fermented bacteria were isolated ,mainly 1019 strains of Acinetobacter Bauman (42 .5％ ) ,followed by Pseudomonas aeruginosa 1016 (42 .4％ ) .The main non fermen-tative bacteria isolated from ICU were 727 strains (30 .3％ ) ,ranking the first in all departments ,and the Acin-etobacter Bauman was the top .The sensitivity rate of Acinetobacter Bauman to antibiotics was decreasing year by year ,as low as 25 .0％ -40 .0％ .Especially in ICU ,the sensitivity rates were less than 10 .0％ .The suscep-tibility rates of Pseudomonas aeruginosa to a variety of antibiotics ,such as ceftazidime ,cefepime ,imipenem , ciprofloxacin ,levofloxacin ,were all increased ,and the sensitivity was >70 .0％ .Conclusion Acinetobacter and Pseudomonas aeruginosa were the main pathogenic bacteria in the clinical distribution of non fermenting bacte-ria .The most sensitive rate of the former to antibiotics was decreasing year by year ,especially the ICU situa-tion was severe ,the sensitivity of the latter was increasing year by year ,which was beneficial to the clinical se-lection of antimicrobial agents .%目的 了解该院2014-2016年的非发酵菌临床分布及对抗菌药物敏感性变迁,为临床提供参考依据.方法 回顾性分析2014-2016年分离出的2398株非发酵菌临床分布及抗菌药物敏感性情况.结果3年间共分离出非发酵菌2398株,主要是鲍曼不动杆菌1019株(42.5％),其次是铜绿假单胞菌1016株(42.4％).ICU主要非发酵菌分离株为727株(30.3％),居所有科室第一,仍以鲍曼不动杆菌占首位.鲍曼不动杆菌对抗菌药物的敏感率绝大多数呈逐年降低趋势,为25.0％～40.0％,尤其是ICU大多数敏感率都低于10.0％.而铜绿假单胞菌对多种抗菌药物如头孢他啶、头孢吡肟、亚胺培南、环丙沙星、左氧氟沙星等敏感率均呈上升趋势,其敏感率均>70.0％.结论 鲍曼不动杆菌和铜绿假单胞菌为非发酵菌临床分布的主要病原菌,前者对抗菌药物的敏感率绝大多数呈逐年降低趋势,尤其是ICU形势严峻;后者的敏感率呈逐年上升趋势,有利于临床选择抗菌药物.
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