重庆地区乙醛脱氢酶2基因Glu504Lys多态性与高血压的相关性分析

摘要

目的 探究乙醛脱氢酶2(ALDH2)基因第504位点(Glu504Lys)多态性与重庆地区高血压的相关性.方法 应用基因芯片法分别检测144例高血压组和193例健康对照组的ALDH2基因型.结果 ALDH2基因型共检测出三种,分别是ALDH2*1/*1(野生型),ALDH2*1/*2和ALDH2*2/*2(突变型),高血压组和对照组野生型和突变型分别为112(77.78%)、32(22.22%)例和114(59.07%)、79(40.93%)例,分布符合Hardy-Weinberg平衡.高血压组野生型比例高于对照组,差异具有统计学意义(P<0.05).logistic回归分析显示,A LD H2基因多态性是高血压发生的独立危险因素.结论 重庆地区A LD H2野生型与高血压的发生关系密切.%Objective To study the acetaldehyde dehydrogenase 2(ALDH2)Glu504Lys polymorphism and the correlation of hypertension in Chongqing area.Methods The ALDH2 genotype of 144 patients hyperten-sion group and 193 healthy people controls group were detected by gene chip.Results Three types of ALDH2 genotypes were detected,which were ALDH2*1/*1(wild type),ALDH2*1/*2 and ALDH2*2/*2(mu-tant).The wild type and mutant type in hypertension group and control group were 112(77.78%),32 (22.22%)and 114(59.07%),79(40.93%)respectively,distribution accorded with Hardy-Weinberg equilibrium.The wild type ratio of hypertension group was higher than that of the control group,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that ALDH 2 gene poly-morphism was an independent risk factor for hypertension.Conclusion The ALDH2 wild type in chongqing is closely related to hypertension.