评价血细胞比容、维生素C和半乳糖等干扰因素对3种便携式血糖仪的影响

摘要

Objective To evaluate the influence of hematocrit(HCT),vitamin C(Vc)and galactose on three portable blood glucose meters to provide some reference for clinical selection of appropriate blood glucose me-ter.Methods 20 heparin anticoagulant venous blood samples in the clinical laboratory department of Nanfang Hospital were selected for verifying the accuracy of blood glucose meter.2 healthy volunteers were selected for collecting 5 w hole blood samples in interferent test.Referring to the detection results of Roche automatic bio-chemical analyzer,the Nova StatStrip Xpress glucometer,Bayer Contour Plus glucometer and Roche Accu-chek Performa blood glucose meter were performed the accuracy verification.The influence of HCT,Vc and galac-tose on the detection results of above three portable blood glucose meters were evaluated.Results The detec-tion accuracy of Nova StatStrip Xpress and the Roche Accu-Chek glucometers all conformed to the require-ments of ISO15197:2013 standards.The detection accuracy of Bayer Contour Plus glucometer only conformed to the requirements of ISO15197:2003 standards.Under the interference of different levels of HCT,Vc and galactose,the detection results of Nova StatStrip Xpress glucometer conformed to the requirements of ISO15197:2013 standards;w hen detecting low concentration of blood glucose,the Bayer Contour Plus glucom-eter was interfered by 10 mg/dL Vc,and other detection results conformed to the requirements of ISO15197:2003 standards;the anti-interference performance of Roche Accu-chek Performa glucometer conformed to the%目的 评价血细胞比容(HCT)、维生素C(Vc)和半乳糖等干扰因素对3种便携式血糖仪的影响,为临床选择合适的血糖仪提供一定参考.方法 选取该院检验科肝素锂抗凝的静脉血标本20份用于血糖仪准确度验证,选取2名健康志愿者的空腹静脉全血标本各5份用于干扰物试验,参考罗氏C501全自动生化分析仪的检测结果,对 Nova StatStrip Xpress 血糖仪、拜安进血糖仪、罗氏卓越血糖仪进行准确度验证,评价HCT、Vc和半乳糖对以上3种便携式血糖仪检测结果的影响.结果 Nova StatStrip Xpress 血糖仪和罗氏卓越血糖仪检测准确度均符合ISO15197:2013标准要求,拜安进血糖仪检测准确度仅符合ISO15197:2003标准要求.在不同水平HCT、Vc、半乳糖干扰下,Nova StatStrip Xpress 血糖仪检测结果均符合ISO15197:2013标准要求;拜安进血糖仪检测低浓度血糖时受到10 mg/dL Vc干扰,其余检测结果均符合ISO15197:2003标准要求;罗氏卓越血糖仪对 HCT的抗干扰性能符合ISO15197:2013标准要求,但受Vc和半乳糖干扰较大.结论 3种便携式血糖仪的准确度和抗干扰性能不同,临床应根据患者实际情况选择合适的血糖仪,确保血糖检测的准确性.