The relationship between staging of hepatic fibrosis and the levels of serum biochemistry

摘要

Objective: To study the relationship between the de-gree of hepatic fibrosis and serum fibrosis markers.Methods: Liver biopsies were performed in 67 pa-tients with hepatitis. The sections were stained withhematoxylin eosin and immunohistochemical stain.Staging of hepatic fibrosis was made microscopically.The serum levels of hyaluronic acid (HA), type Ⅲprocollagen (PC-Ⅲ), laminin (LN), and type Ⅳcollagen (Ⅳ-C) were measured by radioimmunoas-say.Results: The serum levels of HA, PC-Ⅲ, LN andⅣ-C were elevated from S1 to S4 because of the in-crease of hepatic fibrosis. The serum concentrationsof HA, PC-Ⅲ, LN and Ⅳ-C were increased with theprogress of disease, with the highest concentration atthe stage of cirrhosis.Conclusion: The stages of hepatic fibrosis are corre-lated with the serum levels of HA, PC-Ⅲ, LN andⅣ-C, which as markers may play a role in detectingthe degree of hepatic fibrosis.