Changes in serum level of Ghrelin,Tumor Necrosis Factor-α&Interleukin-6in Children with Conegenital Heart Disease

摘要

Objective: To investigate the changes in serum levels of ghrelin, tumor necrosis factor-α and interleukin-6 in Children with Congenital Heart Disease (CHD) at pre and post percutaneous closure of the defects.
　　Method & Materials: We measured the serum levels of gherlin, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) by enzyme linked immunosorbent assays (ELISA) in 67 patients with CHD and in 20 control subjects; and compared these markers of inflammatory reaction between groups ofpre-closure (37 patients) and at the end of 5 minutes (37 patients),1 month (22 patients) and 3 month (8 patients) post percutaneous closure of the defects.
　　Results: Our results showed that the patients with CHD had significantly higher serum level of Ghrelin, TNF-α and IL-6 in comparison of the controls but gradually return towards the baseline levels at the end of 3 months after closure of the defects.
　　Conclusion: The inflammatory reaction is activated in pre-closure and self-limited post-closure in children with CHD.Percutaneous closure could improve the inflammatory process, which is safe and effective in children with CHD.

目录

声明

TABLE OF CONTENTS

ABBREVIATION

ABSTRACT

1．INTRODUCTION

Background of the study

Summary

Purpose of study

2．MATERIAL AND METHODS

3．RESULTS

4．DISCUSSION

5．CONCLUSION

REFERENCES

ACKNOWLEDGEMENT

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