DNA甲基化在肿瘤诊断和治疗中应用的研究进展

摘要

DNA methylation is the most important and distinct form of epigenetic modification. Aberrant DNA methylation has close relationship to tumorigenesis. In this review, we will discuss the roles of abnormal DNA methylation in cancer development, progression, diagnosis, treatment and prognosis.%DNA甲基化是重要的表遗传学修饰方式.启动子区异常高甲基化是抑癌基因表达失活的主要机制之一,与肿瘤的发生密切相关.现重点将DNA异常甲基化研究在临床肿瘤诊断、治疗以及监测等方面的应用及意义作一综述.