登革病毒E蛋白结构域Ⅲ疫苗研究进展

摘要

The ideal dengue vaccines should be low reactogenic, induce life-long protection against infection with any of the four serotypes of dengue viruses, and be affordable. The envelope protein domain Ⅲ of dengue virus has been implicated in receptor binding, and it is also the target of specific neutralizing antibodies.In this article, the current state of knowledge on vaccine candidates based on domain Ⅲ is reviewed.%理想的登革热疫苗应该是副作用小,可以诱导持久的抵抗4个血清型登革病毒感染的保护作用,并且价格合适.登革病毒E蛋白结构域Ⅲ介导受体连接作用并可诱导特异性中和抗体.此文主要介绍利用E蛋白结构域Ⅲ来开发登革热疫苗的研究进展.