多重特异性单克隆抗体研究进展

摘要

The development of diseases seems to be related to several mediators.Drugs targeting one component of a biological system may not achieve desired clinical effects.Multiple antigen-targeting strategies,including combination of antibodies,polyclonal antibodies or antibody mixtures,and bispecific antibodies,are promising ones to increase therapeutic efficacy for treatment of certain complex diseases.However,dual-andpan-specific monoclonal antibodies developed in recent years provide a novel approach for multiple antigentargeting therapies.This article reviews recent adVances in the research of pan-specific monoclonal antibodies.%疾病的形成通常是涉及多个关键介质的复杂过程,因此针对单一成分的抗体药物有时并不能获得较好的临床疗效.多抗原靶向性治疗策略有望提高对一些复杂疾病的治疗效果,它们包括抗体的联合使用、多克隆抗体或混合抗体以及双特异性抗体等.近年来,双重或多重特异性单克隆抗体的出现为多抗原靶向性治疗提供了新策略和方法,此文对多重特异性单克隆抗体的研究进展做一综述.