血清及房水中 IL-6水平与炎症性青光眼的相关性研究

摘要

目的：测定炎症相关性青光眼（简称炎症性青光眼）患者血清及房水中白细胞介素-6（ IL-6）的水平，探讨IL-6在炎症性青光眼发生发展中的作用。　　方法：选取炎症性青光眼患者20例20眼作为试验组（ A组），原发性慢性青光眼（原发性慢性开角型青光眼和原发性慢性闭角型青光眼）患者20例20眼作为高眼压对照组（ B组），老年性白内障患者20例20眼作为正常对照组（C组）。采集三组患者血清及房水标本，通过电化学发光法分别检测血清与房水中IL-6的水平。　　结果：炎症性青光眼组、原发性慢性青光眼组、老年性白内障组血清IL-6水平分别为3．26±2．10，4．20±1．94，3．50±2．24pg/mL，差异无统计学意义（F＝1．080，P＝0．345）。炎症性青光眼组、原发性慢性青光眼组、老年性白内障组房水IL-6水平分别为293．77±38．72，135．27±32．72，115．80±29．97pg/mL，差异有统计学意义（ F＝164．86，P＝0．000），炎症性青光眼组明显高于原发性慢性青光眼及老年性白内障组，差异有统计学意义（P＜0．01；P＜0．01），原发性慢性青光眼组与老年性白内障组相比，差异无统计学意义（P＞0．05）。　　结论：炎症性青光眼患者房水IL-6水平的高表达与炎症反应密切相关，与高眼压状态无明显相关性。%AIM:To discuss the role of interleukin-6 ( IL-6 ) in the development of inflammatory glaucoma by detecting the IL-6 levels in serum and aqueous humor of inflammatory glaucoma patients. METHODS: Totally 20 patients ( 20 eyes ) with inflammatory glaucoma were selected as experimental group, 20 patients ( 20 eyes ) with primary chronic glaucoma ( primary chronic angle-closure glaucoma and primary chronic open angle glaucoma ) as the high intraocular pressure control group, and 20 senile cataract patients ( 20 eyes ) as the normal control group.Three specimens of serum, aqueous humor in three groups were collected and aqueous IL-6 levels were measured through electrochemiluminescence. RESULTS: The serum IL -6 levels in Inflammatory glaucoma group, primary chronic glaucoma group, senile cataract group were 3.26±2.10, 4.20±1.94 and 3.50 ±2.24pg/mL, respectively, which doesn't demonstrate statistically significant differences (F=1.080, P=0.345). The aqueous IL-6 levels in the Inflammatory glaucoma group, primary chronic glaucoma group and senile cataract group aqueous were 293.77±38.72, 135.27±32.72 and 115.80 ± 29. 97pg/mL, respectively, demonstrating statistically significant differences (F=164.86, P=0.000). The Inflammatory glaucoma group was found to be significantly higher than that in the primary chronic glaucoma and senile cataract group (P0.05). CONCLUSION: High expression of IL -6 levels in aqueous humor of inflammatory glaucoma patients is closely associated with inflammation, but it has no significant correlation with high intraocular pressure.