单纯疱疹病毒性角膜炎的发病机制

摘要

Herpes simplex keratitis ( HSK) is one of the most common ocular diseases, which is caused by Herpes simplex virus. More than 90% individuals have been infected with herpes simplex virus(HSV) in his lifetime. HSV establishes both neuronal latency and corneal latency. Stressful stimuli such as UV radiation, fever, stress, hypothermia, hyperthermia and surgical manipulation of the trigeminal ganglia can cause reactivation. The corneal lesions after HSV infection is mainly the result of the immunoreaction in which CD4+ cells appeared to be mediating the pathology, with CD8+ cells seemingly playing a protective role.%单纯疱疹病毒性角膜炎(herpes simplex keratitis,HSK)是一种常见的眼部疾病,由单纯疱疹病毒(herpes simplex virus,HSV)感染引起.人群中超过90%的人曾经感染过HSV.HSV可以在神经组织及角膜组织长期潜伏.在适宜的刺激下,如紫外线照射、发热、精神压力、高温、低温、手术等,病毒活化增殖导致HSK.HSV感染引起的免疫反应是造成角膜组织损害的主要机制.HSK的免疫反应主要是由CD4+细胞介导的,而CD8+细胞对病毒感染具有保护作用.