目的：观察透明质酸酶球旁注射联合α-硫辛酸辅助中药治疗糖尿病性玻璃体积血的效果。 方法：回顾分析67例增生性糖尿病视网膜病变(proliferative diabetic retinophathy, PDR)并发玻璃体积血患者的临床资料,分为治疗组32例给予透明质酸酶球旁注射联合α-硫辛酸静脉点滴辅助活血化瘀中药治疗,对照组35例只给予活血化瘀中药治疗。 结果：随访2~3mo,治疗组的总有效率(78%)明显高于对照组(57%),两组比较差异有统计学意义(P<0.05)。其中玻璃体积血时间2 wk以上的患者两组治疗有效率分别为22%和25%,两组比较差异无统计学意义( P>0.05)。 结论：透明质酸酶球旁注射联合α-硫辛酸辅助活血化瘀中药治疗PDR并发玻璃体积血,相比单用中药治疗效果更好,但也只对早期出血有效,而对出血时间超过2 wk以上者则无明显效果。%AIM: To study the effectiveness of hyaluronidase periocular injection combined with α - lipoic acid and Chinese medicine in the treatment of diabetic vitreous hemorrhage. METHODS: Retrospective analysis of 67 patientswith proliferative diabetic retinophathy ( PDR ) and vitreous hemorrhage, were divided into two groups: treatment group and control group. There were 32 cases in every group, the treatment group were giving hyaluronidase periocular injection combined with α - lipoic acid intravenously and with traditional Chinese medicine in promoting blood circulation to remove blood stasis, control group were only given Chinese medicine treatment in promoting blood circulation to remove blood stasis. RESULTS: Followed up 2-3mo, the total efficiency of treatment group ( 78%) was better than control group (57%), there was statistically significant difference ( P<0-05 ) . The efficiency of the two groups' patients with vitreous hemorrhage more than 2wk time was 22% and 25% respectively, there was no statistically significant difference in the two groups (P>0. 05). CONCLUSION: Hyaluronidase periocular injection combined with α-lipoic acid and Chinese medicine in the treatment of PDR combined with vitreous hemorrhageis more effective than only use Chinese medicine. But it only has effect for the early, over 2wk, it has no significant effect.
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