Adjuvant therapy of dementia using alpha-lipoic acid or derivative, is effective in combination with antidementia or neurotransmission improving agents in improving cognitive function in e.g. Alzheimer's disease patients

摘要

The use of alpha -lipoic acid compounds (I) is claimed for the adjuvant therapy of dementia, where (I) is selected from alpha -lipoic acid in reduced or oxidized form or its derivatives having an intact dithiolan structure in the form of enantiomers or salts, amides, esters, thioesters, ethers or metabolites. An independent claim is included for a composition containing (I) in combination with at least one anti-dementia agent (II) or at least one neurotransmission improving agent (III). - ACTIVITY : Nootropic; neuroprotective; antiparkinsonian; anti-HIV. - MECHANISM OF ACTION : Antioxidant.