Effects of adjuvant folic acid + vitamin b12 therapy on Hcy metabolism, neurotrophy and nerve injury in patients with Alzheimer''''s disease

摘要

Objective: To explore the effects of adjuvant folic acid + vitamin b12 therapy on Hcy metabolism, neurotrophy and nerve injury in patients with Alzheimer''s disease (AD). Methods:A total of 104 patients with Alzheimer''s disease were divided into control group (n=52) and study group (n=52) by random number table. Control group received clinical routine treatment, and study group received routine treatment combined with adjuvant folic acid and vitamin b12 therapy. The differences in Hcy metabolism, neurotrophy and nerve injury were compared between the two groups before and after treatment. Results: Before treatment, there was no statistically significant difference in serum contents of Hcy, neurotrophy indexes and nerve injury indexes between the two groups. After 3 months of treatment, serum Hcy of study group was lower than that of control group;serum neurotrophy indexes nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), insulin-like growth factor 1 (IGF-1) and insulin-like growth factor 2 (IGF-2) contents were higher than those of control group;serum nerve injury indexes myelin basic protein (MBP), neuron-specific enolase (NSE), neurofilament heavy (NfH) and S100 calcium-binding protein B (S100B) contents were lower than those of control group. Conclusion: Adjuvent folic acid and vitamin b12 therapy can effectively reduce Hcy content, increase neurotrophy and relieve nerve injury in patients with Alzheimer''s disease.