• AIM: To investigate the preventive effect of 1g/L bromfenac sodium hydrate ophthalmic solution on macular edema after phacoemulsification.•METHODS:In this prospective, randomized, controlled clinical trial, the cases with age related cataract after phacoemulsification combined with intraocular lens implantation were randomly divided into two groups, each group of 118 eyes. The cases in experimental group received the treatment of 1g/L bromfenac sodium hydrate ophthalmic solution for 2d preoperatively and 4wk postoperatively, combined with tobramycin dexamethasone eye drops for 2wk postoperatively. The cases in control group received the treatment of tobramycin dexamethasone eye drops for 2wk postoperatively. Central subfield mean thickness( CSMT) was measured within 2d before surgery as well as on 1d, 1, 4, 12wk after surgery and the incidence of macular edema was calculated after surgery.•RESULTS:There was no significant difference in CSMT between two groups before surgery and on 1d, 1, 12wk after surgery (P>0. 05). CSMT was significantly lower in experimental group (251. 57 ± 6. 814μm) than in control group (262. 41±7. 295μm) on 4wk after surgery (P0.05)；术后4wk 试验组CSMT 为251.57±6.814μm,低于对照组的262.41±7.295μm,差异有统计学意义(P<0.05)；术后1d,1、4、12wk试验组黄斑水肿发生率分别为0、0、0.9%、0.9%,对照组分别为0、0.9%、8.5%、1.7%,两组黄斑水肿发生率比较,仅术后4wk差异有统计学意义(P<0.05)。结论：白内障超声乳化术前和术后应用1g/L溴芬酸钠水合物滴眼液,能有效预防术后黄斑中心亚区域增厚,减少黄斑水肿发生率。
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