生化指标对中老年人群白内障发病的影响

摘要

目的：探讨生化指标对中老年人群白内障发病的影响。方法：选择2014-01/2016-01间我院诊治的132例244眼中老年白内障患者作为观察组,并选择同期我院收治的156例312眼非白内障患者作为对照组。根据所有入选者年龄的不同分为3个亚组,其中40~59岁为A组,60~79岁为B组,80岁以上为C组。检测所有入选者的血液生化指标,主要包括周血白蛋白( ALB)、球蛋白( GLB)、总蛋白( TP)、葡萄糖( GLU)、尿素氮( BUN)、尿酸( UA)、肌酐(Cr)、谷丙转氨酶(ALT)、乳酸脱氢酶(LDH)、碱性磷酸酶(ALP)、总胆固醇(TC)、钙离子(Ca)、钠离子(Na)、钾离子( K)和磷离子( P)等指标,并进行相关性分析。结果：两组患者的ALP、ALT、K、P、LDH水平差异无统计学意义( P>0.05)；而观察组患者的 ALB、GLB、TP、GLU、BUN、Cr、TC、Ca、Na水平显著高于对照组,差异有统计学意义(P<0.05)。经多因素分析发现,ALB、GLU、BUN、Cr、Ca与白内障的发生发展存在显著相关性。以年龄组为单位分析结果显示：A组中观察组患者的ALB、GLU、Na水平显著高于对照组,差异有统计学意义(P<0.05)；B组中白内障患者的ALB、BUN、Cr、GLU、Na水平显著高于对照组,差异有统计学意义(P<0.05)；C 组中白内障患者的BUN、Cr、GLU、Na水平显著高于对照组,差异有统计学意义(P<0.05)。结论：中老年白内障患者外周血中ALB、TP、BUN、Cr、TC、Ca水平均显著升高,这些变化可能与白内障病变存在着一定的关联性。%•AIM: To discuss the effect of biochemical indexes on condition of middle aged and senior people with cataract.•METHODS: A total of 132 patients with cataract from Jan. 2014 to Jan. 2016 in our hospital were collected as the observation group. And 156 patients besides cataract were chosen as the control group. All entrants were divided into group A (40-59y), group B (60-79y) and group C (≥80y) according to the age. The biochemical indexes of all entrants were checked, including ALB, GLB, TP, GLU, BUN, UA, Cr, ALT, LDH, ALP, TC, Ca, Na, K and P. And all indicators were given phase relationship analysis.•RESULTS:There were no statistically significant in the level of ALP, ALT, K, P, LDH between observation group and control group. The level of ALB, GLB, TP, GLU, BUN, Cr, TC, Ca, Na in observation group were higher than those in the control group. The results of Logistic regression between two groups were as follow the level of ALB, GLU, BUN, Cr, Ca might be enrolled as risk factors for cataract. In group A, the level of ALB, GLU, Na in observation group were higher than those in the control group. In group B, the level of ALB, BUN, Cr, GLU, Na in observation group were higher than those in the control group. In group C, the level of BUN, Cr, GLU, Na in observation group were higher than those in the control group (P<0. 05).•CONCLUSION:The level of ALB, TP, BUN, Cr, TC, Ca was significantly increased which suggested that those change might associate with the pathogenesis of cataract.