炎症免疫相关信号通路在干眼发病机制中的研究进展

摘要

干眼是泪液和眼表的一种多因素疾病，其中炎症是干眼发病机制中最关键的因素，因此干眼的炎症机制及抗炎治疗已成为近年研究的热点。但关于干眼患者眼表所发生的信号传导通路改变目前知之甚少，尤其是炎症因子在干眼中激活相关信号传导通路以及受后者所调控的研究还比较少也比较新。本文主要针对炎症因子在干眼中激活相关信号通路及受相关通路调控的研究进展进行综述。%•Dry eye ( DE) is a multifactorial disease of tear film and ocular surface. Inflammation in the ocular surface plays a main role in the pathogenesis of DE. Accordingly, inflammation and therapies that inhibit immune response may become topic for DE in recent years. Unfortunately, there are few studies about signaling pathway that has changed in ocular surface of DE. It is novel and there are few researches on how inflammation active signaling pathway and how it was regulated by signaling pathway on DE. This paper presents a review about inflammation active signaling pathway and its regulation on signaling pathway of DE.