星点设计-响应面法优选肺炎口服液的提取工艺

摘要

To optimize the extraction technology of oral liquid for pneumonia.Methods; The inde-pendent variables were alcohol sediment concentration, liquid - material ratio and extraction time. The dependent variable was extraction rate of total extract from oral liquid for pneumonia. Linear or nonlinear mathematic models were used to estimate the relationship between independent and dependent variables. Central composite design and response surface methodology were used to optimize the process of extraction. The prediction was carried out through comparing the observed and predicted values. Results; The optimum technological parameters were as follows; alcohol sediment concentration 75. 76% , liquid - material ratio of 1:9. 19 and extraction time 2. 08 hours. The highest extraction rate of essential oil was 10. 46mg/ml which was agreed with model predictions. Conclusion;The extraction technology is simple, reliable and highly predictive.%目的:采用星点设计-响应面法优化肺炎口服液的提取工艺.方法:以醇沉浓度,料液比,提取时间为自变量,提取物总含量为因变量,通过对自变量各水平的多元线性回归及二项式拟合,用星点设计-响应面法选取最佳工艺,并进行预测分析.结果:最佳工艺条件为醇沉浓度75.76％,料液比1:9.19,提取时间2.08h,在此最佳条件下,肺炎口服液中提取物总含量的最大估计值为10.46mg/ml.实验结果与模型预测值相符.结论:方法简便合理,稳定,可预测性较优.