Objective To investigate the relationship between liver fibrosis stage and serum HBV DNA level and liver function markers in patients with chronic hepatitis B. Methods Liver biopsy was performed to measure liver inflammation activity and fibrosis degree, and the serum HBV DNA level and liver function markers were detected. Results Liver fibrosis stage was correlated with liver inflammation activity. The degree of liver inflammation was positively correlated with that of liver fibrosis (P=O.000, rs= 0.657). Liver inflammation grade was positively correlated with the serum HBV DNA level (P=0.000, rs=0.602), and so was liver fibrosis stage despite a lower correlation (P=0.000, rs=0.385). Serum albumin and prealbumin levels decreased in the patients with stage 4 fibrosis (P＜0.05). Conclusions The degree of liver fibrosis is correlated with liver inflammation activity. The serum HBV DNA level is positively correlated with the degree of liver inflammation and fibrosis. Liver function markers cannot serve as predictors for early stage of liver fibrosis.%目的 探讨慢性乙型肝炎肝纤维化程度与血清HBV DNA水平及肝功能的关系.方法 采用肝脏活体组织检查确定肝组织炎症活动度及纤维化程度,同时检测血清HBV DNA水平及肝功能.结果 肝组织病理的肝纤维化分级与炎症活动分期有关,肝脏炎症程度与纤维化程度呈正相关,P=0.000,rs=0.657.肝脏炎症分期与HBV DNA水平呈正相关,P=0.000,rs=0.602.肝组织纤维化分级与HBV DNA水平呈正相关,P=0.000,但相关性较低,rs=0.385,在S4期清蛋白及前白蛋白水平减低,P＜0.05.结论 肝纤维化程度与肝组织炎症活动度有关.HBV DNA高水平复制与肝脏炎症及纤维化程度相关.肝功能临床指标不能早期提示患者肝纤维化病变.
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