慢性乙型肝炎患者血清HA、PⅢ、CⅣ、LN含量与肝纤维化程度关系的探讨

摘要

目的探讨慢性乙型肝炎患者血清 HA、P Ⅲ、C Ⅳ、LN 含量与肝纤维化程度的关系。方法用放射免疫法检测56例慢性乙肝患者血清 HA、P Ⅲ、C Ⅳ及 LN 的含量，运用临床资料和病理结果等进行的肝纤维化临床分期，用统计学方法对血清学指标和肝纤维化程度进行相关性分析。结果患者肝组织学的炎症程度分级与纤维化分期正相关（P ＜0.01）。血清 HA、P Ⅲ、Ⅳ C、LN 水平与肝脏纤维化程度呈正相关，有统计学意义（P ＜0.01）。结论慢性乙型肝炎患者血清 HA、P Ⅲ、C Ⅳ、LN 的含量在一定程度上反映肝纤维化的进展情况，对慢性乙肝患者肝纤维化的诊断和动态检测具有临床意义。%　　Objective To study the relationship between the levels of serum HA, PⅢ, CⅣ, LN and indexes of live fibrosis in the patients of chronic hepatitis. Methods The levels of serum HA, PⅢ, CⅣ, LN in 56 cases of chronic hepatitis were measured by radio immunoassay. The liver fibrosis stage was done by combined with clinical characteristics and pathologic result. The correlation analysis was done by statistical methods. Results The value of HA、PⅢ、ⅣC、LN in the chronic hepatitis group was significantly higher than that in the normal group (P<0.01). The levels of HA、PⅢ、ⅣC、LN increased gradually with live cirrhosis graded. The difference is apparent among the different grades (P<0.01). Conclusion The levels of serum HA, PⅢ, CⅣ, LN are related to the degree of liver fibrosis. And these indexes are valuable for chronic hepatitis diagnoses.