136例尿道口尖锐湿疣流行病学分析及5-氨基酮戊酸光动力治疗疗效

摘要

目的：分析136例尿道口尖锐湿疣患者情况，并评价其5-氨基酮戊酸光动力疗法治疗的临床疗效。方法回顾性分析2013年1月—2014年12月在我科接受5-氨基酮戊酸光动力治疗的136例尿道口尖锐湿疣的患者的临床资料，分析其流行病学特点，并总结疗效。结果136例尿道口尖锐湿疣中HPV DNA分型以6型和11型为主；20～40岁男性患者占绝大多数；传播方式以性传播为主。患者接受5-氨基酮戊酸光动力治疗结束后疣体完全消退，随访6个月复发率为4.4%，随访12个月后未见复发患者，治愈率100%。主要不良反应为照射部位水肿、疼痛及红斑。结论尿道口尖锐湿疣主要由性传播引起，5-氨基酮戊酸光动力疗法治疗尿道口尖锐湿疣清除率高、不良反应小，可作为尿道口尖锐湿疣的治疗选择。%ObjectiveTo analyze 136 patients with urethral condyloma acuminatum, and evaluate the efficacy of photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) on urethral condyloma acuminatum.MethodsA retrospective analysis was made for 136 patients with urethral condyloma acuminatum treated with topical ALA-PDT in our department from January 2013 to December 2014. The epidemiological characteristics and the efficacy were analyzed.ResultsOf the 136 patients with urethral condyloma acuminatum, HPV-DNA type 6 and type 11 dominated, male patients aged 20-40 years old accounted for the majority, and sexual transmission was the main mode of transmission. After being treated with topical ALA-PDT, the warts disappeared completely. During the 6-month follow-up after the treatment, the recurrence rate was 4.4%; after 12-month follow-up, no recurrence was found with a curative rate of 100%. The main adverse reactions of ALA-PDT included edema, pain and erythema on local skin.ConclusionsUrethral condyloma acuminatum is mainly caused by sexual transmission. ALA-PDT is an effective and safe therapy for urethral condyloma acuminatum, with a higher rate of wart elimination and fewer adverse reactions.