HCV感染是世界范围内慢性肝病的主要原因之一,且HCV感染也是肝细胞癌发生的重要原因.以干扰素或聚乙二醇干扰素为基础的抗病毒治疗在过去20余年间使大量HCV感染患者达到了清除病毒的治疗目的,即持续病毒学应答.近年来随着直接抗病毒药的应用,患者中持续病毒学应答的比例得到了进一步提高,且因直接抗病毒药较低的不良反应率使得更多患者能够得到治疗.本文对慢性HCV感染者应用不同的抗病毒治疗方案获得持续病毒学应答后对原发性肝癌的发生率的影响进行综述.%Hepatitis C virus infection is one of the main causes of chronic liver diseases in the world and is an important reason for the development of hepatocellular carcinoma. Interferon or pegylated interferon based antiviral therapy has eradicated the virus in a huge amount of hepatitis C infected patients, which has been known as sustained virological response for two decades. With the use of direct-acting antivirals, a further increase has been seen in the percentage of sustained virological response. In addition, due to low rate of side effects, direct-acting antivirals have been applied in more patients. This study reviewes the influence of sustained virological response to the occurrence of hepatocellular carcinoma after chronic hepatitis C virus infected patients who are treated with different antiviral therapies.
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