等渗和低渗对比剂在CT增强扫描中的不良反应分析

摘要

Objective To compare the incidence of acute adverse reaction between isotonic and hypotonic contrast medium in enhanced CT scanning. Methods 1152 patients who received enhanced CT examination in our hospital from June 2014 to December 2014 were selected. They were divided into isotonic group and hypotonic group according to their contrast medium in enhanced CT scanning. Compared the incidence of acute adverse reaction and its constitution between two groups.Results There were 325 cases in isotonic group and 827 cases in hypotonic group. The incidence of mild, moderate and severe acute adverse reaction between two groups was 6.46% vs. 17.53% (21cases vs. 145 cases), 0.31% vs. 0.48% (1 case vs. 4 cases) and 0% vs. 0.12% (0 case vs. 1 case). There were significant differences in terms of the incidence of acute adverse reaction (Z=23.952, P<0.05) and the incidence of mild acute adverse reaction (X2=23.360, P<0.05) between two groups while the incidence of moderate and severe acute adverse reaction was of no significant difference.Conclusion Isotonic contrast media can reduce the incidence of mild acute adverse reaction in enhanced CT scanning.%目的比较等渗性对比剂和低渗性对比剂在CT增强扫描中的急性不良反应发生率差别。方法分析2014年6月至2014年12月便利抽样选取本院完成CT增强扫描的患者1152例。根据使用的对比剂种类分为等渗对比剂组和低渗对比剂组，比较两组患者不良反应的发生率和不良反应的构成有无差别。结果等渗组患者共325例，低渗组827例。两组对比轻、中、重度不良反应发生率分别为6.46%与17.53%（21例和145例），0.31%与0.48%（1例和4例）及0%与0.12（0例和1例），总急性不良反应发生率（Z=23.952，P<0.05）和轻度不良反应发生率（X2=23.360，P<0.05）差异有统计学意义。中、重度急性不良反应两者差异无统计学意义。结论等渗性对比剂能够降低CT增强扫描中轻度急性不良反应的发生率。