Sterol regulatory element binding protein 1 (SREBP-1) is one of the important nuclear transcription factors. SREBP-1 can maintain lipids dynamic equilibrium by regulating the expression of enzymes required for synthesis of endogenous cholesterol, fatty acids, triglycerides and phospholipids. Anomalies of SREBP-1 and its target genes can cause a series of metabolic diseases such as insulin resistance, type II diabetes, heart dysfunction, vascular complications andrnhepatic steatosis. la these years, the development of high-throughput technologies has greatly expanded our knowledge about SREBP-1 target genes and the pattern of transcriptional regulation. Here we reviewed recent research progress of SREBP-1, with a focus on the protein structure, activation process, DNA binding sites and target genes. Most importantly, we showed the transcriptional regulatory networks based on omics datasets, which will contribute to a better understanding of the role of SREBP-1 in lipid metabolism and provide new clues for the treatment of lipid metabolism disorders.%固醇调节元件结合蛋白1(Sterolregulatory element-bindingproteinl,SREBP-1)是重要的核转录园子之一,能调控内源性胆固醇、脂肪酸、甘油三酯和磷脂合成所需酶的表达,以维持血脂动态平衡.研究表明,SREBP.1 及其靶基因网络的异常可引起胰岛素抵抗,Ⅱ型糖尿病,心功能紊乱、血管并发症和肝脂肪变等一系列代谢性 疾病.近年高通量组学技术的发展极大扩展了对SREBP-1靶基因及其转录调控模式的了解.文章对SREBP-1 蛋白结构、活化过程、DNA结合位点及其调控的靶基因等方面的研究进展进行了综述.并着重介绍了基于组学 数据的转录调控网络的构建,这将有助于更好的认识SREBP-1在脂类代谢中的作用,为深入探讨脂质代谢性疾 病的治疗提供新线索.
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