MicroRNA调控哺乳动物骨骼肌发育

摘要

MicroRNA (miRNA) is a class of short non-coding RNA, which is about 22 bp in length. In mammals, miRNA exerts its funtion through binding with the 3′-UTR region of target genes and inhibiting their translation. Skeletal muscle development is a complex event, including: proliferation, migration and differentiation of skeletal muscle stem cells; proliferation, differentiation and fusion of myocytes; as well as hypertrophy, energy metabolism and conversion of muscle fiber types. The miRNA plays important roles in all processes of skeletal muscle develop-ment through targeting the key factors of different stages. Herein we summarize the miRNA related to muscle devel-opment, providing a better understanding of the skeletal muscle development.%MicroRNA(miRNA)是一类长度大约为22 bp的小分子非编码RNA,广泛存在于哺乳动物中,部分miRNA表达具有时空和组织特异性.哺乳动物中miRNA主要通过与靶基因3′UTR区结合抑制其翻译,调控机体生物学功能.miRNA在哺乳动物骨骼肌发育中发挥重要调节作用.哺乳动物骨骼肌发育是一个复杂的生物学过程,包括骨骼肌干细胞增殖、迁移、分化,成肌细胞增殖、分化、肌管融合,肌纤维肥大,能量代谢,纤维类型转换等.miRNA参与骨骼肌发育的各个环节,通过靶向各个时期的关键因子调控骨骼肌发育.本文对miRNA在骨骼肌发育中的调控作用进行了综述,以期为深入理解骨骼肌发育规律提供参考.