千金藤素对大鼠体内非索非那定药动学的影响

摘要

Objective To study- the effect of cepharanthine on phmarmcokinetics of fexofenadine in rats.Methods 10 rats were randomly divided into two groups, which were treated with fexofenadine as group A and fexofenadine plus cepharanthine as group B.The blood samples were collected at different time points fiom two groups.The serum concentration of fexofenadine sodium was determined by HPLC and the pharmcokinetic parameters were calculated with 3P97 program and analyzed.Results The Cmax and AUC0-l were significantly elevated in the drug combination group compared with those in the group treated with fexofenadine alone.The AUC0-l in group A and group B was ( 5.379 ± 1.570 ) and ( 8.088 ± 1.760 )mg · h · L -1( P＜0.01 ); the Cmax was ( 1.225±0.770 ) and ( 1.417±0.440 ) μg · mL-1( P＜0.05 ), the AUC0-l and Cmax were increased 7.09％( P＜0.05 ) and 15.67％ ( P＜0.05 ), respectively; however, no significant differences were noted with regard to Ka, MRT and t1/2.Conclusion The marked increase of Cmax and AUC0-t of fexofenadine when fexofenadine and cepharanthine were coadministered, indicating that the oral bioavailabilities of fexofenadine were significantly increased.%目的 研究千金藤素对大鼠体内非索非那定药动学的影响.方法 SD大鼠10只随机分为两组,分别灌胃给予非索非那定、千金藤素+非索非那定,不同给药时间采集血样.采用高效液相色谱法测定非索非那定血药浓度,绘制药物浓度-时间曲线,用3P97药动学软件拟合药动学参数,并进行统计分析.结果 非索非那定和千金藤素+非索非那定组Cmax分别为(1.225±0.770),(1.417±0.440) μg·mL-1 (P＜0.05);AUC0-t分别为(5.379±1.570),(8.088±1.760) mg·h·L-1(P＜0.01).千金藤素+非索非那定组AUC0-t和Cmax分别增加7.09%(P＜0.05)和15.67%(P＜0.05);两组Ka、MRT和t1/2差异无统计学意义.结论 与千金藤素合用后,非索非那定在大鼠体内的生物利用度增加,千金藤素对非索非那定在大鼠体内药动学具有显著影响.