注射用头孢西丁钠与氟康唑氯化钠注射液配伍的稳定性

摘要

Objective To study the compatible stability of cefoxitin sodium for injection and fluconazole and sodium chloride injection under ambient temperature.Methods The changes of contents of cefoxitin sodium and fluconazole were determined simultaneously by RP-HPLC, and those of appearance, pH value were observed within 6 hours.Results There were no significant changes in the contents, appearance and pH values of the compatible solution for 4h.Conclusion Cefoxitin sodium for injection is inadvisable to mix with fluconazole and sodium chloride injection for 4 h under ambient temperature.%目的 考察室温[(25±1)℃]下,注射用头孢西丁钠与氟康唑氯化钠注射液配伍的稳定性.方法 采用反相高效液相色谱法测定配伍液中头孢西丁钠与氟康唑0～6 h内的含量变化,并观察配伍液的外观及pH值.结果 注射用头孢西丁钠与氟康唑氯化钠注射液4 h内配伍液外观、pH及含量均无明显变化.结论 在室温下,注射用头孢西丁钠与氟康唑氯化钠注射液配伍后4 h内可使用.