虎尾轮根提取物对肾阳虚模型小鼠的影响

摘要

Objective To study effects of different extracts from Roots of Uraria crinita on kidney-YANG deficiency mice induced by hydrocortisone.Methods Kidney-YANG deficiency mice were induced by hydrocortisone ,effects of different extracts from roots of Uraria crinita were observed by observing physical signs , measuring ant-oxidative stress ability and reproductive organ weights.Results Total ointment ,acetic ether extract and n-butanol extract significantly enhanced appetite ,increased body weight, promoted growth and development , raised spleen and thymic weight index, prominently alleviated reproductive organs ' atrophy, obviously eliminated fatigue, and enhanced anti-oxidative stress ability of mice.Conclusion Roots of Uraria crinita can improve the life quality of Kidney -YANG deficiency mice, the acetic ether extract and n -butanol extract are the major active extracts on kidney -YANG deficiency.%目的 探讨虎尾轮根不同提取部位对肾阳虚模型小鼠的影响.方法 采用氢化可的松致小鼠肾阳虚模型,对小鼠体征、抗氧化能力、应激能力、睾丸质量进行测定.结果 虎尾轮根提取物的总膏、乙酸乙酯部位、正丁醇部位可明显提高小鼠食欲,增加体质量,促进生长发育,增加脾脏、胸腺质量,提高脾脏和胸腺指数,明显减轻肾阳虚小鼠生殖器官萎缩,有明显的抗疲劳作用,可提高小鼠的应激能力.结论 虎尾轮根可改善肾阳虚小鼠的生存质量,其乙酸乙酯部位、正丁醇部位是其抗肾阳虚主要的药效部位.