串联混合输注装置中丙氨酰谷氨酰胺配伍稳定性考察

摘要

Objective To investigate the compatible stability of alanylglutamine by using continuous series infusion device,and provide experimental evidence for reasonable clinical use of alanylglutamine. Methods pH,osmolality and quantity of insoluble particles were measured by using pH meter, automatic freezing osmometer and intelligent particle detector respectively.A HPLC method was built for the determination of the content of alanylglutamine. Results pH and quantity of insoluble particles of the two tested groups did not change significantly over time. Osmolality and the content of alanylglutamine fluctuated greatly in the first half an hour. Conclusion Continuous series infusion device may not mix each bottle of solution very well.It is suggested to premix these solutions to ensure the stability of the dilution ratio and the osmotic pressure of the mixture in the process of the infusion.%目的 考察串联混合输注装置中丙氨酰谷氨酰胺的配伍稳定性,为合理输注丙氨酰谷氨酰胺提供实验依据. 方法 选取临床常与丙氨酰谷氨酰胺配伍的两种氨基酸注射液,经串联输注装置连接后滴注,测定不同时刻流出的输注液pH值、渗透压、不溶性微粒数和丙氨酰谷氨酰胺含量. 结果 在串联混合输注方式下,实验各配伍组pH值、不溶性微粒数量随时间变化不明显,但渗透压和丙氨酰谷氨酰胺含量在输注0.5 h时变化较大. 结论 串联混合输注装置在整个输注过程中不能很好混匀丙氨酰谷氨酰胺和氨基酸注射液,建议尽可能提前混匀各配伍溶液以保证输注过程中丙氨酰谷氨酰胺的稀释比例和配伍液渗透压的稳定性.