多种生化指标在不同性别早发冠心病患者中的特征分析

摘要

目的：探讨多种生化指标在不同性别早发冠心病患者中的流行特征和规律。方法选取早发冠心病患者332例，按性别分为两组进行比较，其中男性147例，女性185例。收集研究对象的临床资料及采集患者入院24 h内空腹12 h肘静脉血，记录血糖（GLU）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL）、载脂蛋白A（apoA）、载脂蛋白B （apoB）、LP（a）（脂蛋白a）、纤维蛋白原定量（FG）、D-二聚体定量（DD）、总胆红素（TBIL）、尿酸（UA）的数值。结果男性组的文化程度、月均收入、高血压病史、超重（ BMI≥24）、吸烟饮酒史比例高于女性组（ P均＜0．05）。女性组TC、HDL-C、LDC、apoA、FG、DD水平高于男性组，而TG、TBIL、UA水平则显著低于男性组，差异有统计学意义（P均＜0．05）。两组GLU、apoB、LP（a）水平差异无统计学意义（P均＞0．05）。结论大部分心血管病危险因素在早发冠心病患者中存在着性别差异，因此有必要在中青年人群中进行整体心血管风险的评估，并采取综合性个体化干预措施，以降低未来心血管不良事件的风险。%Objective To investigate the epidemiological characteristics and patterns of risk factors in patients of different genders with premature coronary heart disease.Methods A total of 332 patients with premature coronary heart disease were divided into female group (n=147) and male group (n=185).Collecting their clinical data and venous blood without food in admission within 24h.Writing down the values of blood glucose records ( GLU) ,total cholesterol ( TC) ,triglyceride ( TG) ,high density lipoprotein ( HDL-C) ,low-den-sity lipoprotein protein (LDC),apolipoprotein A (APOA),apolipoprotein B (APOB),lipoprotein a (LP (a)),fibrinogen (FG),D-Di-mer (DD),the total bilirubin (TBIL) and uric acid (UA).Results The cultural level,the average monthly income,the history of hyper-tension,the CHD family history,overweight (BMI>=24) and the history of smoking and drinking in male group were higher than those in female group ( P<0.05 ).The levels of total cholesterol ,high density lipoprotein ,low density lipoprotein ,apolipoprotein A ,fibrinogen and D-Dimer in female group were higher than those in male group , but the triglycerides level , total bilirubin level and uric acid level were significantly lower than theirs ( P <0.05 ).The levels of blood glucose , apolipoprotein B , lipoprotein ( a ) in two groups showed no significant difference in statistics ( P>0.05 ).Conclusion Most of cardiovascular risk factors in patients with premature coronary heart disease are different in different genders.It is necessary to assess the overall cardiovascular risk in middle -aged crowd,and take a compre-hensive individualized interventions to reduce future cardiovascular the risk of adverse events .