血清白蛋白、非结合胆红素对于新生儿黄疸的临床应用价值

摘要

Objective To investigate the value of serum albumin and unconjugated bilirubin in neonatal jaundice .Methods A retro-spective analysis of 84 cases of neonatal jaundice from October , 2011 to December , 2012 in the department grouped according to different causes and diseases was done , and unconjugated bilirubin , unconjugated bilirubin/albumin and β2 microglobulin were observed and com-pared.Results With the increasing severity from moderate to severe , stained yellow from the non -nuclear to nuclear jaundice , unconjugated bilirubin, unconjugated bilirubin/albumin andβ2 microglobulin levels significantly increased , and the difference was statistically significant ( P<0.05 );while in different etiologies , hemolytic jaundice , non-infectious jaundice obstructive jaundice bilirubin , unconjugated biliru-bin/albumin and β2 microglobulin in turn increased significantly ,and the difference was statistically significant ( P<0.05 ).Conclusion Neonatal jaundice patients with different etiologies are in different levels of jaundice bilirubin , unconjugated bilirubin/albumin and β2 mi-croglobulin, and the etiologies can be judged according to the indicators above and give responding treatment .%目的：探讨血清白蛋白、非结合胆红素在新生儿黄疸的检查运用价值。方法回顾性分析2011－10～2012－12间来我科确诊为黄疸的84例新生儿患者，根据不同病因及病情进行分组，观察并比较各组患儿之间非结合胆红素、非结合胆红素／白蛋白以及β2微球蛋白的水平。结果随着病情严重程度的增高，由中度到重度，由无核黄染到有核黄染，非结合胆红素、非结合胆红素／白蛋白以及β2微球蛋白水平明显升高，且差异有统计学意义（ P＜0.05）；而在不同病因中，梗阻性黄疸、溶血性黄疸、感染性黄疸患儿的非结合胆红素、非结合胆红素／白蛋白以及β2微球蛋白水平依次明显升高，差异有统计学意义（ P＜0.05）。结论不同病因的新生儿黄疸患儿非结合胆红素、非结合胆红素／白蛋白以及β2微球蛋白水平存在显著差异，其中以感染性黄疸较为严重，临床上应根据患儿上述指标水平判断病因并给以相应的治疗手段。