Objective: To evaluate the efficacy of tamsulosin in treatment of lower ureteral calculi. Method: A total of 90 consecutive patients with single radiopaque lower ureteral calculi were enrolled in the study. The stone diameter was 0. 4 — 1. 0cm and patients were 21-72 years. All patients were diveded into two groups! 45 cases in each group ). The control group were treated with lavoofloxacin ( 0. 2g bid ) and chi-nese medicine Paishi Decoction ( ldose qd ). The tamsulosin group received the same medicines in the control group plus tamsulosin( 0. 2mg qd ). There's no significant differences in concerning age, gender distribution and maximum stone diameter of two groups. All patients were treated for 10 days and followed up for 15 days. Efficacy was evaluated in term of stone expulsion rate, expulsion time, pain episodes, analgesic use and adverse drug reaction during a week of follow up. Result:The successful stone expulsion rate was 86. 7%( 39/45 ) in the tamsulosin group, which was significantly higher than 57. 8% in the control group ( P< 0. 01 ). Mean expulsive calculi time of the control group and the tamsulosin group were 7. 51 ±2. 34 days,5. 02±1.27 days respectively. There was statistically significant difference ( P<0.05 ). The pain episodes rate and analgesic use rate were 17.8% ( 8/45 ) and 6. 7%( 3/45 ) in the tamsulosin group, which were also significantly lower than those in the control group, which were 42.2%( 19/45 ) and 28.9%( 13/45 ), respectively ( P<0. 05 ). All the patients could tolerate the expulsive calculi therapy and no obvious side effects were found. Conclusion:Tamsulosin can be useful to shorten the duration of the expelling stone, relieves renal colic episode and significantly improve the expulsive calculi rate in the lower ureter. Tamsulosin in the treatment of lower ureteral stones ( 0. 4-1. 0cm in diameter ) is safe.%目的:评价坦索罗辛在输尿管下段结石辅助排石中的临床效果.方法:选取90例确诊单纯输尿管下段结石的患者,年龄21-72岁,结石0.4-1.0cm,随机分为两组(每组45例):对照组给予左氧氟沙星(0.2g 2次/d)及中药排石汤(1剂 1次/d )治疗;坦索罗辛组在对照组治疗基础上加用坦索罗辛(0.2mg,1次/d).两组间在年龄、性别、结石直径等差异上均无统计学意义.治疗10天,随访至15天,观察结石排出率及排出时间、肾绞痛发生率、镇痛剂使用等情况和药物不良反应.结果:坦索罗辛组的结石完全排出率为86.7%(39/45),显著高于对照组的57.8%(26/45),两组的排石率有显著性差异(P<0.01);对照组、坦索罗辛组的排石时间分别为7.51±2.34d、5.02±1.27d,两组比较有显著性差异(P<0.05);坦索罗辛组肾绞痛发生率和镇痛剂的使用率为17.8% (8/45)和6.7%(3/45),也均显著低于对照组的42.2%(19/45)和28.9%(13/45),(P均<0.05).两组患者在治疗期间内均未发现明显的不良反应,无因不能耐受而退出者.结论:坦索罗辛在输尿管下段结石辅助排石中,能缩短排石时间,降低肾绞痛发作频率,明显提高排石率,安全性高.
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