目的:探讨对高龄冠心病患者应用辛伐他汀强化降脂治疗的疗效.方法:随机将93例年龄≥70岁的冠心病患者分为强化降脂治疗组46例、常规剂量组47例,每天分别给予40mg、20mg辛伐他汀治疗,连用8周后比较两组患者各血脂指标变化及不良反应情况.结果:服药8周后,两组TC、TG及LDL-C水平均有明显降低(P<0.01),而HDL-C均有显著升高(P<0.01).强化降脂治疗组降脂达标率为71.74%(33/46),较常规剂量组42.55%(20/47)有显著差异(X2=8.08,P<0.01);强化降脂组不良反应率为16.52%,较常规剂量组10.64%稍有升高,但无限制差异(X2=0.11,P>0.05).结论:40mg/d辛伐他汀强化降脂治疗疗效显著,安全可靠.%Objective: To explore the effect of simvastatin on the advanced aged patients with coronary heart disease. Method: 93 cases of advanced aged patients with coronary heart disease were randomly divided into the group with amount of reinforcement ( n = 46 ) and the group with amount of routine ( n = 47 ). The group with amount of reinforcement were given simvastatin with the dose of 40mg/d, and the group with a-mount of routine were given simvastatin with the dose of 20mg/d. And then examined the blood of two groups and observed the adverse response. Result: After 8 weeks, The level of TC,TG and LDL-C in two groups were reduced ( P<0. 01 ), The level of HDL-C in the two groups were improved significantly ( P<0. 01 ). The rate up to the standard of the group with amount of reinforcement was 71. 74% ( 33/46 ), which was higher than that of the group with amount of routine, with the rate up to the standard of 42. 55% ( 20/47 ) ( X =8. 08 ,P<0. 01 ). The rate of the adverse response between two groups has no difference ( X =0. 11 ,P >0. 05 ). Conclusion: The effect of simvastatin with 40mg/d on the advanced aged patients with coronary heart disease is effective and safe.
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