老年原发性高血压患者踝肱指数脉压指数与认知功能的关系

摘要

Obective:To study the relationship between ankle-brachial index (ABI), pulse pressure index (PPI) and cognition function in the elderly patients with essential hypertension. Method: ABI were detected in 610 elderly hypertensives. Patients were divided into abnormal group( ABI≤0. 9,n = 220) (observation group ) and normalgroup (1.3 > ABI>0.9, n = 390 ) ( control group ). Cognitive functions were evaluated by mini-mental state examination ( MMSE). Scores of MMSE and PPI between the two groups were compared. Result: Scores of MMSE were significantly lower in observation group than that of control group(23. 4 ±1.8 vs28. L±1.4,P<0. 05). And there were significant differences between the two groups in ability of instant memory, calculation, prolonged recall (P<0. 05) . PPI were significantly higher in observation group than that of control group(0.464±0.31 vs 0.438±0.53 ,P<0.05). Conclusion: The lower ABI and higher PPI is associated with cognitive impairment in the elderly patients with essential hypertension. It has important clinical value to screening ABI and PPI to findind intervene cognitive impairment early in the elderly hypertensives.%目的:探讨老年原发性高血压患者踝肱指数、脉压指数与认知功能的关系.方法:通过对610 例老年原发性高血压患者进行踝肱指数(ankle-brachial index,ABI)检测,分为ABI 减低组(观察组)(ABI≤0.9,n＝220)和ABI 正常组(1.3＞ABI＞0.9,n＝390)(对照组).两组均以枟简明智能状态检查表枠(mini-mental state examination,MMSE)进行认知功能检测,比较两组间MMSE 评分的差异并分析两组脉压指数(pulse pressure index,PPI)差异.结果:ABI 减低组MMSE 评分明显低于ABI 正常组(23.4±1.8 比28.1±1.4,P＜0.05).其中两组计算力、即时记忆力、延迟回忆力评分差异有统计学意义(P＜0.05),定向力、语言表达能力差异无统计学意义(P＞0.05);观察组PPI 明显高于对照组(P＜0.05).结论:老年原发性高血压患者ABI 降低、PPI 升高是引起认知功能障碍的重要因素,筛查ABI及PPI 对早期发现认知功能障碍并进行干预具有重要临床意义.