硝酸甘油与重组人脑利钠肽治疗急性非ST 段抬高型心肌梗死合并心力衰竭的对比研究

摘要

Objective: To evaluate the effect and adverse reactions of recombinant human brain natri-uretic peptide (rhBNP) and nitroglycerin (NTG) for acute non-ST segment elevation myocardial infarction (NSTEMI) combined with heart failure. Method: RhBNP group of 30 patients were given rhBNP treatment on the basis of conventional drug treatment, NTG group of 32 patients received conventional drug therapy based on the use of NTG. Vital signs were observed before and after treatment, the degree of difficulty breathing, brain natriuretic peptide ( BNP) and the related changes in hemodynamics. Result: The two groups in clinical performance (including symptoms and signs) , functional class, left ventricular ejection fraction, urine volume(average urine volume per hour) was superior to NTG group , There was significant difference (P<0. 05). Conclusion; rhBNP for non - ST - segment elevation acute myocardial infarction ( NSTEMI) with heart failure has more significant effect than NTG, but with a low incidence of adverse reactions.%目的:对比观察重组人脑利钠肽(rhBNP)与硝酸甘油(NTG)治疗急性非ST 段抬高型心肌梗死(NSTEMI)合并心力衰竭的疗效与安全性.方法:rhBNP 组30 例,在常规药物治疗的基础上给予rhBNP 治疗;硝酸甘油(NTG)组32 例,给予常规药物治疗的基础上加用NTG.观察两组用药前后生命体征、呼吸困难程度、脑钠肽(BNP)、相关血流动力学指标的变化及不良反应.结果:rhBNP 组的症状、体征改善、左室射血分数、心功能分级、尿量方面均显著优于NTG 组,差异有统计学意义( P＜0.05).治疗期间两组均无明显不良反应出现.结论:rhBNP 治疗NSTEMI 合并心力衰竭的疗效比NTG更显著,且安全可行.