丹红注射液对急性胰腺炎血 D-二聚体和 C-反应蛋白的影响及临床疗效观察

摘要

目的：观察使用丹红注射液治疗急性胰腺炎前后，血中D-D及CRP 变化情况，从而探讨丹红注射液对急性胰腺炎患者血中D-D及CRP 影响，并观察其临床疗效。方法：选取本院86例急性胰腺炎患者，随机分为两组，对照组33例采用常规治疗；治疗组53例，在对照组治疗的基础上，给予丹红注射液静脉滴注。两组患者在确诊后即刻及治疗1d、3d、5d、7d时抽取静脉血，分别检测血D-二聚体（ D-D）及C-反应蛋白（ CRP ）含量，同时检测两组血常规白细胞计数、动脉血氧分压及血淀粉酶检查。并分析两组生存率、重症患者肠鸣音恢复时间、住院时间以及半年复发率的百分比。结果：治疗后两组间D-D、CRP、白细胞计数、动脉氧分压、血淀粉酶方面具有统计学意义（P＜0．05）。在肠鸣音恢复时间、住院时间之间存在明显差异（ P＜0．01），两组半年复发率具有明显差异（ P＜0．01），对照组5例，治疗组2例，但两组生存率无明显差异（ P＞0．05），对照组为30例，治疗组为49例。结论：丹红注射液可明显降低血D-D及CRP ，改善血液流变性，增加胰腺血流量，明显改善胰腺微循环，是治疗急性胰腺炎的有效方法之一。%Objective:To observe the change of D-D and CRP in patients with acute pancreatitis after the treatment of Danhong injection and discuss the clinical curative effect of Danhong injection on acute pan -creatitis.Method:86 cases of patients with acute pancreatitis in our hospital , and were randomly divided in-to two groups , 33 cases with conventional treatment in control group , cases with Danhong injection intrave-nous drip in treatment group 53, on the basis of the control group treatment .After treatment of 1d, 3 d, 5 d, 7d, two groups was immediately draw blood and detected the level of D -dimer ( D -D) and C -reactive protein ( CRP ) .As the same time , the two groups all were detected white blood cell count , blood oxygen partial pressure and blood amylase examination and analysis the two groups with survival times , the recovery time of bowel sounds in severe acute pancreatitis , hospital stay , and the percentage of the half year relapse . Result:Between the two groups after treatment , the difference of D-D CRP , WBC count and arterial oxygen partial pressure, blood amylase has statistical significance (P <0.05).And in terms of recovery time of bow-el sounds, hospital stay and the half year relapse rate , two groups have obvious differences (P <0.01), taking the half year relapse rate for example , control group 5 cases, treatment group 2 cases.But the differ-ences of survival rate between two groups were no statistical significance (P >0.05), control group 30 ca-ses, treatment group 49 cases .Conclusion:Danhong injection can obviously decrease D-D and CRP to im-prove blood rheology , increase pancreatic blood flow and significantly improve the pancreas microcircuLation . So Danhong injection is one of the effective method of treatment of acute pancreatitis .