目的：研究全脑同期推量调强放疗（ SimuLtaneous moduLated radiotherapy ，SMR）对脑多发性转移癌（ MuLtiple cerebral metastatic carcinoma ， MCMC ）患者疗效及预后情况。方法：选取我院2010年7月至2013年7月，收治的80例MCMC病患作为观察对象。以数字法随机分成两组。观察组实施全脑SMR，对照组实施常规全脑放疗。对比两组疗效以及预后情况。结果：观察组RR为72．50％（29/40），较对照组的47．50％（19/40）明显高。差异均具有统计学意义（均P＜0．05）。两组病患全部顺利完成治疗，未见Ⅲ级以上NS反应以及2度以上骨髓抑制。观察组恶心、呕吐为0．93±0．15，白细胞降低为1．32±0．21，血小板下降为0．76±0．11，贫血为1．32±0．24，较对照组的1．01±0．12，1．44±0．22，0．82±0．12，1．44±0．25明显更低。结论：全脑SMR 治疗MCMC，疗效显著。毒副反应患者可耐受，安全可行，值得推荐。%Objective:To study the curative effect and prognosis of whole brain simultaneous moduLated radiotherapy (SMR) for multiple cerebral metastatic carcinoma (MCMC) patients.Method:The total of 80 MCMC patients in our hospital from July 2010 to July 2013 were randomly divided into two groups .The ob-servation group received whole brain SMR;the control group received routine whole brain radiotherapy , com-pared the curative effect and prognosis of two groups .Result: The total effective rate in observation group [72.50%(29/40)] was higher than the control group [47.50%(19/40)].The differences were statistical-ly significant ( P<0.05) .Patients of two groups all successfully completed treatment had no neurotoxic reac-tions above grade III and 2 degrees of bone marrow suppression .The observation group ’ s nausea , vomiting [0.93 ±0.15], decreased white blood cells [1.32 ±0.21], thrombocytopenia [0.76 ±0.11] , anemia [1. 32 ±0.24], were lower than the control group ’s [1.01 ±0.12, 1.44 ±0.22, 0.82 ±0.12, 1.44 ±0.25]. The differences were statistically significant (P<0.05).Conclusion:Whole brain SMR desirable has a good effect on MCMC patients , Toxicity is acceptable .It is worthy of recommendation .
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