Objective: To investigate the independent risk factors of ventilator -associated pneumonia( VAP ) in patients of intensive care units ( ICU ) , and to search for corresponding nursing interventions . Method:The clinical data of 120 patients with mechanical ventilation of ICU were retrospectively analyzed . The patients were assiqned according to whether they suffered from VAP or not .Statistically significant varia-bles were screened by single factor analysis , and then Logistic regression analysis was conducted to confirm the independent risk factors of VAP .Corresponding nursing interventions were consequently formulated .Re-sult:The single factor analysis of patients with VAP and without VAP revealed that the differences in intuba-tion way, acid inhibitor, time of mechanical ventilation , length of stay in ICU, sedation and coma scores , use of hormones, and use of antibacterials at 48h before use of a ventilator were statistically significant (P<0.05).And multiplicity revealed that only acid inhibitor , time of mechanical ventilation , coma score, and use of antibacterials at 48h before use of a ventilator were independent risk factors of VAP in ICU ( the OR values were 4.674, 2.681, 7.542, and 3.690, respectively).Conclusion:Analysis on independent risk fac-tors of VAP in ICU is beneficial to formulating scientific nursing interventions , and establishes the foundation for decreasing the incidence of VAP .%目的：探讨重症监护室患者呼吸机相关性肺炎（ VAP ）的独立危险因素，寻找相应的护理干预措施。方法：回顾性分析重症监护室120例机械通气患者的临床资料，根据发生VAP 与否分组，先行单因素分析筛选出有统计学意义的变量，再行Logistic回归逐步分析确定VAP 的独立危险因素，制定相应的护理措施。结果：发生VAP 与未发生VAP的患者单因素分析显示在插管方式、抑酸剂、机械通气时间、入住重症监护室时间、镇静评分、昏迷评分、使用激素和应用呼吸机前48h使用抗菌药物等比较，差异有统计学意义（ P＜0．05）。多因素分析只有抑酸剂、机械通气时间、昏迷评分及应用呼吸机前48h使用抗菌药物是重症监护室VAP发生的独立危险因素（ OR值分别为4．674、2．681、7．542和3．690）。结论：通过对重症监护室VAP 独立危险因素的分析，有利于制定科学的护理干预措施，为降低VAP的发生率奠定基础。
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