Objective:To investigate the detection rate and abnormal type of abnormal chromosome karyotype in infertile patients.Methods:1032 infertile patients' peripheral blood lymphocytes were detected by G banding karyotype analysis.Results:51 cases of chromosomal abnormalities were found in 1032 male patients,the detection rate was 4.94%.Among them,there are 3 cases of sex chromosomal abnormalities,11 cases of autosmal abnormalities,37 cases of chromosome polymorphism changed,the 37 cases state including 8 cases of sex chromosomal polymorphism changed and 29 cases of autosomal polymorphic changed.Most clinical manifestations are weak symptoms,azoospermia and spouse repeated abortion.Conclusion:In male infertility patients,not only need to carry out routine analysis of semen,but also carry their abnormal chromosomes or chromosome polymorphisms detected to prevent patients from transmitting these abnormal chromosomes to the next generation,resulting in its offspring of infertility.%目的:探讨不育症患者异常染色体核型的检出率和异常类型.方法:对1032例不育症患者外周血淋巴细胞进行G显带染色体核型分析.结果:1032例男性患者中共发现51例染色体异常者,检出率为4.94%.其中性染色体异常者3例,常染色体异常者11例,染色体多态性改变37例,其中性染色体多态性改变有8例,常染色体多态性改变有29例.临床表现多为少、弱精症,无精症和配偶反复流产.结论:在男性不育症患者中,不仅需要进行精液常规分析,还要对其携带异常染色体或染色体多态性进行检测,避免患者将这些异常染色体遗传给下一代,造成其后代的不孕不育.
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