沙丁胺醇联合异丙托溴铵对慢性阻塞性肺病患者的疗效及Borg评分的影响

摘要

Objective:To observe the efficacy of salbutamol combined with ipratropium bromide in treatment of chronic obstructive pulmonary disease (COPD).Methods: 128 patients with COPD were individed into two groups randomly, patients in observation group (n=64) were given salbutamol aerosol joint isopropyl bromide aerosol on the basis of conventional treatment, and patients in control group (n=64) were given salbutamol aerosol on the basis of conventional treatment, two groups'clinical curative effect after 2 period of treatment were compared.Results: The total effective rate of observation group was 96.9%, significantly different compared with the control group (P<0.05);The level of VC, FEV1,FEV1/FVC,PEER and PaO2 were significantly higher than the control group (P<0.05),and PaCO2 was significantly lower than the control group (P < 0.05) after treatment;The Borg score of observation group was better than the control group (P<0.05).Conclusions: Salbutamol combined with ipratropium bromide has a good efficacy in chronic obstructive pulmonary disease.And it is worthy to have a clinical promotion.%目的:探讨沙丁胺醇联合异丙托溴铵对慢性阻塞性肺病的临床疗效.方法:选取128例慢性阻塞性肺病患者,随机分为两组,观察组患者在常规治疗的基础上给予沙丁胺醇气雾剂联合异丙托溴铵气雾剂治疗,对照组患者在常规治疗的基础上给予沙丁胺醇气雾剂治疗,持续治疗2个疗程后对比两组临床疗效.结果:治疗组治疗总有效率96.9%,显著高于对照组(P<0.05),观察组的患者肺活量(VC)、第1秒用力呼气容积(FEV1)、第1秒用气呼气量(FEV1)与用力肺活量(FVC)的比值(FEV1/FVC),峰流速(PEER)和氧分压(PaO2)均明显高于对照组患者,二氧化碳分压(PaCO2)低于对照组,差异均具有统计学意义(P<0.05);观察组的Borg评分情况优于对照组,差异具有统计学意义(P<0.05).结论:沙丁胺醇联合异丙托溴铵待对慢性阻塞性肺病有较好的临床疗效,值得推广应用.