巴曲酶联合银杏叶注射液治疗突发性耳聋的疗效及对患者凝血功能的影响

摘要

目的:探讨巴曲酶联合银杏叶注射液对突发性耳聋患者的临床疗效及对患者凝血功能的影响.方法:选取143例突发性耳聋患者,随机分为对照组( n＝71)及治疗组( n＝72) ,两组患者均给予银杏叶注射液进行基础治疗,治疗组在基础治疗的基础上联合巴曲酶治疗,连续治疗2周.治疗后统计两组临床疗效;检测并比较治疗前后两组患者纯音听阈及凝血功能指标的变化;统计两组治疗期间不良反应.结果:治疗组总有效率为90.28%,较对照组的71.83%显著升高( P＜0.01) ;与治疗前比较,治疗后两组患者纯音听阈均显著降低,且治疗组显著低于对照组(P＜0.01);与治疗前比较,治疗后两组患者PT及APTT均显著缩短( P＜0.05或P＜0.01) ,且治疗组显著短于对照组( P＜0.01) ;治疗后两组血清FIB水平显著降低,且治疗组显著低于对照组( P＜0.01) ;两组血清D-D水平显著升高( P＜0.05或P＜0.01) ,且治疗组显著高于对照组( P＜0.01) ;治疗组不良反应发生率为5.56%,较对照组的16.90%显著降低( P＜0.05) .结论:巴曲酶联合银杏叶注射液可有效改善突发性耳聋患者听力及凝血功能,并有效减少相关不良反应,疗效显著优于银杏叶注射液单用.%Objective: To explore the clinical efficacy and the effect of the injection of baotase combined with ginkgo biloba in patients with sudden deafness. Methods: A total of 143 patients with sudden deafness were randomly divided into control group ( n ＝ 71) and treatment group ( n ＝ 72) . Both groups of patients were treated with ginkgo biloba injection. The treatment group was based on the basic therapy combined with the treatment of balthase, continuous treatment for 2 weeks. After treatment, 2 groups of clinical efficacy were calculated. To detect and compare the changes of the pure acoustic threshold and coagulation function of the two groups before and after treatment. The adverse reactions during the treatment of 2 groups were calculated. Results: The total effective rate of treatment group was 90.28%, significantly higher than 71.83% in the con-trol group (P＜0.01). Compared with the treatment before treatment, the pure acoustic threshold of the two groups was significantly reduced after treatment. The treatment group was significantly lower than the control group (P＜0.01); After treatment, both PT and APTT were significantly shortened after treatment (P ＜0.05 or P＜0.01) . The treatment group was significantly shorter than the control group ( P ＜ 0.01) ; The serum FIB levels were significantly lower in the 2 groups after treatment, and the treatment group was significantly lower than the control group ( P＜0.01) . The serum d-d levels were significantly higher in 2 groups ( P ＜0.05 or P＜0.01), and the treatment group was significantly higher than the control group (P＜0.01). The incidence of adverse reactions in the treatment group was 5. 56%, which was significantly lower than that in the control group ( P ＜ 0.05) . Conclusion: The combination of Batroxobin and ginkgo leaf injection can effectively im-prove hearing and coagulation function in patients with sudden deafness, and reduce the related adverse reac-tions effectively. The curative effect is significantly better than that of ginkgo leaf injection.