目的:探讨替罗非班(TIR)结合氯吡格雷(CLO)治疗急性心肌梗死(AMI)的临床疗效及其对患者血清炎性细胞因子水平的影响.方法:选取我院2015年1月至2017年1月收治的 AMI 患者119例作为研究对象,通过简单随机法分为两组.观察组(60例)予以 TIR 结合 CLO 治疗,对照组(59例)仅予CLO治疗.比较两组的临床疗效,治疗前后血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏 C-反应蛋白(hs-CRP)水平及不良反应的发生情况.结果:治疗后,观察组总有效率为95. 0%,明显高于对照组(81.4%,P<0.05).两组治疗后14d 时,血清IL-6、TNF-α、hs-CRP 均明显低于治疗前(P<0.01),且观察组血清IL-6、TNF-α、hs-CRP 明显低于对照组(P<0.01).两组治疗期间不良反应总发生率分别为6.7%、5.1%,比较无显著差异(P>0.05).结论:替罗非班结合氯吡格雷治疗急性心肌梗死更能有效控制机体炎症反应,提高治疗效果,且安全性较高.%Objective:To explore the clinic effect of tirofiban(TIR) combined with clopidogrel(CLO) on acute myocardial infarction(AMI) and the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α) and high sensitivity C-reactive protein (hs-CRP) in serum. Methods:119 cases of patients with AMI admitted in our hospital from January 2015 to January 2017 were selected as research objectives,and accord-ing to simple random method,those patients were divided into two groups. The observation group (60 cases) was treated by TIR combined with CLO,while the control group(59 cases) was treated by CLO. The clinical effect,changes of serum IL-6,TNF-α,hs-CRP levels before and after treatment as well as the incidence of adverse reactions were compared between two groups.Results:After treatment,the overall effective rate of ob-servation group was 95.0%,which was significantly higher than that of the control group (81.4%,P<0.05). The serum IL-6,TNF-α, hs-CRP levels of both groups after treatment were significantly lower than those before treatment(P<0.01),and the serum IL-6,TNF-α,hs-CRP of the observation group were significant-ly lower the in the control group at same time (P<0.01). The total incidence of adverse reactions in the two groups was 6.7% and 5.1%,respectively,and there was no significant difference between the two groups. (P>0.05). Conclusion:Tirofiban combined with clopidogrel could effectively control the inflammation and im-prove the treatment effect with high safety.
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